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ACQUIRED PURE RED–CELL APLASIA IN ADULTS
Author(s) -
Teoh P. C.,
Tan David K. S.,
da Costa J. L.,
Chew B. K.
Publication year - 1973
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1973.tb115115.x
Subject(s) - pure red cell aplasia , chlorpropamide , etiology , prednisolone , aplasia , medicine , surgery , gastroenterology , endocrinology , bone marrow , diabetes mellitus
Acquired pure red‐cell aplasia is a very rare disorder and some patients are found to have an associated thymic tumour. This paper reports three cases of acquired red celt aplasia, the first case histories involving Singapore Chinese. The first patient, with a condition of an unknown aetiology, failed to respond to corticosteroid and androgen therapy, whereas the second patient, whose red cell aplasia was probably induced by chlorpropamide, had a haematological remission after withdrawal of chlorpropamide and administration of corticosteroids. The third patient who developed this disorder six months after the removal of a thymic tumour achieved an impressive clinical improvement with a combination of prednisolone and methyltestosterone therapy. The prevalence, haematological picture, pathology, aetiology and treatment of acquired pure red‐cell aplasia are discussed.