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THE DOSAGE OF SEPTRIN
Author(s) -
FOWLE A. S. E.
Publication year - 1973
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1973.tb111182.x
Subject(s) - extracellular , extracellular fluid , pharmacokinetics , intracellular , chemistry , plasma concentration , plasma levels , kidney , pharmacology , trimethoprim , chromatography , endocrinology , biochemistry , medicine , antibiotics
The pharmacokinetics of trimethoprim (TMP) and sulphamethoxazole (SMX), the two components of Septrin, are not identical. Different concentration ratios therefore occur in tissues and plasma. TMP is distributed in both intracellular and extracellular fluid, whereas SMX circulates In extracellular fluid only. Intracellular fluid concentrations of TMP are approximately twice the concurrent plasma level in most instances. In practice, the dosage of Septrin which will produce satisfactory plasma and tissue levels in adults is two tablets twice daily, that is, a total of 320 mg of TMP and 1,600 mg of SMX daily. Both compounds are well absorbed. TMP and SMX are principally excreted via the kidney. Dosage modification and, in some cases, assay of TMP and total SMX plasma levels are therefore recommended when renal function Is impaired.