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CIRCULATORY EFFECTS OF STABLE PLASMA PROTEIN SOLUTION (SPPS)
Author(s) -
TORDA T. A.,
HARRISON G. A.,
MCCULLOCH C. H.,
WRIGHT J. S.,
STACEY R.,
ROBERTSON M.
Publication year - 1973
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1973.tb110695.x
Subject(s) - cardiac output , circulatory system , vasodilation , vascular resistance , medicine , cardiology , peripheral resistance , diastole , albumin , blood pressure , globulin , chemistry , anesthesia
Rapid infusion of 3 to 4 ml/kg of SPPS consistently caused a fall in systolic and diastolic pressures. This was accompanied by increased cardiac output, indicating that the fall in pressure was a result of reduced peripheral resistance. In patients on cardio‐pulmonary bypass, SPPS reduced the systemic resistance to about half its initial value. Recovery was incomplete in five minutes. A control infusion of human albumin in Hartmann's solution did not produce comparable effects. The globulin fraction of SPPS is thought to contain a vasodilator substance.