Premium
THE SHORT–TERM EFFECTS OF ASPIRIN ON THE RAT KIDNEY: FURTHER OBSERVATIONS
Author(s) -
ARNOLD L.,
COLLINS CATHERINE,
STARMER G. A.
Publication year - 1973
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1973.tb110622.x
Subject(s) - aspirin , inducer , kidney , necrosis , pharmacology , drug , medicine , endocrinology , chemistry , biochemistry , gene
It has been shown previously that acetylsalicylic acid (aspirin) causes renal tubular necrosis and that this effect diminishes with continued administration of the drug. The experiments reported here were undertaken to examine further the development and persistence of this tolerance. The tolerance was almost completely lost after a treatment‐free interval of three weeks. While small repeated doses given over 12 hours produced some tubular necrosis in a few animals, similar and even smaller doses spread over a few days resulted In a lessening of the effects of a single large dose given subsequently. Some protection was also achieved by prior administration of a known enzyme inducer, phenobarbitone sodium, but another enzyme inducer, 3,4‐benzpyrene, had no effect. Alkalinization of the urine failed to affect the aspirin‐Induced lesions at the dosage levels used.