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THE INFLUENCE OF DIAGNOSTIC CRITERIA ON THE MORTALITY FINDINGS IN THE UNIVERSITY GROUP DIABETIC PROGRAMME STUDY OF DIABETIC THERAPY
Author(s) -
GRAY R. H.
Publication year - 1973
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1973.tb110572.x
Subject(s) - medicine , placebo , disease , diabetes mellitus , selection bias , clinical trial , intensive care medicine , placebo group , physical therapy , pathology , alternative medicine , endocrinology
The University Group Diabetic Programme (UGDP) clinical trial of diabetic therapy demonstrated a higher mortality from cardiovascular disease amongst patients treated with oral hypoglycasmic agents. However, these results may have been biased by imbalances between treatment groups in the proportion of patients who were unequivocally diabetic. In order to eliminate this potential bias and to increase the specificity of the diabetic diagnosis, the UGDP mortality findings have been reassessed, using multiple diagnostic criteria as a basis for case selection. The use of multiple diagnostic criteria increases the mortality differences between the patients treated with oral hypoglycasmic agents and those treated by placebo and diet. This reinforces the original findings of the UGDP study.