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THE USE OF TRIMETHOPRIM–SULPHAMETHOXAZOLE IN URINARY TRACT INFECTIONS IN DOMICILIARY PRACTICE
Author(s) -
DUNGAN RAE W.
Publication year - 1973
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1973.tb110545.x
Subject(s) - medicine , trimethoprim , urinary system , rash , vomiting , urine , sulfamethoxazole , incidence (geometry) , antibiotics , surgery , dermatology , microbiology and biotechnology , physics , optics , biology
One hundred and sixty‐seven patients with symptoms of urinary tract infection were treated with courses of trimethoprim and sulphamethoxazoie for up to 14 weeks. By the very nature of the practice, the patients admitted to the trial tended to be those suffering from chronic and intractable infection, which tested the efficacy of the combination in realistic conditions. The success rate for the usual simple Escherichia coll infections was 94%. Twenty‐six per cent of patients in the group as a whole achieved sterile urine at two weeks, while, with prolongation of treatment to 14 weeks, sterile urine was achieved by 63%. Unwanted effects, which may or may not have been related to the drug, were noted in 12 cases; all were mild and readily reversible. Therapy was discontinued In two cases because of skin rash, and in two others because of vomiting. No incidence of hæmopoietic or renal toxicity was observed. A common problem with broad‐spectrum antibacterials is monilial overgrowth; this was not seen during the trial. All E. coli isolated in the study were sensitive to Septrin, and no resistant organisms emerged as a result of the intermittent therapy.