Premium
REVERSIBLE TOXIC PSYCHOSIS AFTER CEPHALEXIN
Author(s) -
SAKER B. M.,
MUSK A. W.,
HAYWOOD E. F.,
HURST P. E.
Publication year - 1973
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1973.tb110518.x
Subject(s) - medicine , cephalosporin , gastrointestinal tract , endocarditis , impaired renal function , antibiotics , renal function , microbiology and biotechnology , biology
Cephalexin Is a new semisynthetic derivative of cephalosporin C, which has the property of being well absorbed from the gastrointestinal tract when administered orally (Wick, 1967). It has a broad range of antibacterial activity and has been used successfully in treating bacterial endocarditis (Zabransky et alii, 1969). Clinical studies have shown that the drug is removed from circulation almost entirely by the kidney (Braun et alii, 1968). Prolongation of serum activity has been demonstrated In patients with impaired renal function (Clark and Turck, 1968; Kunin and Finkleberg, 1970). Side effects have been remarkably mild and mainly consist of gastrointestinal upsets, skin rashes and monillal vaginitis (Clark and Turck, 1968). We report here the case of a patient with moderately severe uræmia with suspected bacterial endocarditis, who developed convulsions and a toxic confusional state after administration of cephalexin.