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THE ACTION OF TRIMETHOPRIM–SULPHAMETHOXAZOLE AGAINST URINARY PATHOGENS
Author(s) -
Smith D. D.,
Bell S. M.,
Levey J. M.,
Loy Y. T.
Publication year - 1972
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1972.tb50914.x
Subject(s) - trimethoprim , microbiology and biotechnology , sulfamethoxazole , bacilli , chemistry , biology , bacteria , antibiotics , genetics
Trimethoprim‐sulphamethoxazole sensitivity tests were carried out on 21 strains of coliform bacilli, and eight of these strains were studied in greater detail. All strains were sensitive to trimethoprim alone. A synergistic action was evident in strains sensitive to both compounds, but not in those resistant to sulphonamide. Bactericidal activity attributable to the combination was not demonstrated. The emergence of trimethoprim‐resistant mutants from most strains was rapid in the presence of trimethoprim alone, and also from sulphonamide‐resistant strains in media containing mixtures of trimethoprim and sulphamethoxazole. Sensitivity testing and the therapeutic implications of in‐vitro studies of the antibacterial action of this compound are discussed briefly.