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DOUBLE–BLIND TRIAL COMPARING TRIMETHOPRIM–SULPHAMETHOXAZOLE (BACTRIM) WITH AMPICILLIN IN TREATING URINARY INFECTIONS
Author(s) -
Wren Barry G.
Publication year - 1972
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1972.tb50913.x
Subject(s) - ampicillin , medicine , urinary system , trimethoprim , clinical trial , double blind , sulfamethoxazole , drug , antibiotics , pharmacology , microbiology and biotechnology , placebo , biology , pathology , alternative medicine
Because the use of the combination of sulphamethoxazole and trimethoprim (Bactrim, Roche) has been shown to be so useful in controlling urinary Infections, it was decided to conduct a double‐blind trial using ampicillin to compare the efficacy of the combination with a known excellent urinary chemotherapeutic agent. Ampicillin was found to have in‐vitro activity against 75% of urinary microorganisms, but to have only 66% clinical response, whereas Bactrim was found to be effective against organisms in over 95% of cases, in both laboratory and clinical results. Bactrim was shown to be the drug of choice in treating urinary tract infection in postoperative and post‐partum patients in a double‐blind trial.