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REVIEW OF 12 MONTHS’ TREATMENT WITH L‐DOPA IN PARKINSON'S DISEASE, WITH REMARKS ON UNUSUAL SIDE EFFECTS
Author(s) -
Wodak J.,
Gilligan B. S.,
Veale J. L.,
Dowty B. J.
Publication year - 1972
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1972.tb47582.x
Subject(s) - dysphagia , medicine , disease , parkinson's disease , side effect (computer science) , pediatrics , akinetic mutism , levodopa , surgery , anesthesia , computer science , programming language
In a series of 16 Parkinsonian patients receiving L‐dopa over a period of 12 months, statistical analysis showed that most patients, although their condition improved from their pretreatment status, failed to maintain their early level of response. This finding was clinically unexpected and contrasts with the experience of others. Possible sources of error are discounted. Some potentially deceptive or unusual side effects encountered in a larger group of patients are mentioned; these include weight loss, flushing, dyspnoea, dysphagia, restlessness, logorrhœa, akinetic mutism and oropharyngeal dystonias.