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THE TREATMENT OF CHRONIC MESANGIOCAPILLARY (MEMBRANOPROLIFERATIVE) GLOMERULONEPHRITIS WITH IMPAIRED RENAL FUNCTION
Author(s) -
KincaidSmith Priscilla
Publication year - 1972
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1972.tb47498.x
Subject(s) - membranoproliferative glomerulonephritis , medicine , nephrotic syndrome , renal function , proteinuria , glomerulonephritis , dipyridamole , cyclophosphamide , gastroenterology , urine , urology , mesangial proliferative glomerulonephritis , kidney , chemotherapy
Mesangiocapillary (membranoproliferative) glomerulonephritis carries a poor prognosis when associated with impaired renal function, the nephrotic syndrome and hypertension. Treatment with combined cyclophosphamide, dipyridamole and anticoagulants in a group of 16 patients with impaired renal function, all of whom had the nephrotic syndrome and half of whom had malignant hypertension, produced a highly significant improvement in cumulative survival curves (at 30 months, P < 0.0001). The course in treated patients differed strikingly from that reported by other groups and from the course in our own untreated patients. Serial renal biopsies showed considerable improvement in condition during treatment and the characteristic features of increased mesangial matrix and “double contours” in the peripheral capillary loops disappeared in some patients. In addition, in five patients the proteinuria disappeared or was present in only trace amounts, and there was considerable reduction in quantitative counts of red blood cells in the urine.