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ESR AND AGGREGATION OF RED CELLS AFTER ADDITION OF FRUCTOSE OR GLUCOSE: EFFECT OF ABO BLOOD GROUPS
Author(s) -
Dintenfass Leopold
Publication year - 1972
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1972.tb47388.x
Subject(s) - fructose , tonicity , abo blood group system , saline , chemistry , medicine , endocrinology , isotonic solutions , isotonic saline , isotonic , hypertonic saline , biochemistry
Fructose and glucose isotonic and hypertonic solutions were added to anticoagulated blood, and erythrocyte sedimentation rates (ESR) were studied using Westergren tubes. ESR values, corrected for plasma viscosity and hæmatocrit, gave an estimation of the degree of aggregation of red cells. Saline, fructose and glucose decrease ESR and aggregation of red cells. In isotonic systems, fructose is more effective (P < 0.02) than glucose in disaggregating red cells, but only In patients with blood group A. In hypertonic systems fructose appears also to be more effective (P = 0.07). In isotonic systems, fructose shows a greater aggregation‐lowering effect on blood group A than on blood group O (P < 0.05), while glucose shows no such effect. In hypertonic systems, both fructose and glucose show a greater disaggregating effect on blood groups A and B than on blood group O P < 0.05). In the blood of diabetics, the disaggregating effect of fructose and glucose is significant only in patients with blood group A (P < 0.05, P < 0.02). Blood groups play no role whatsoever if the blood is extended with the native plasma or saline.