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AN EVALUATION OF THE SECRETIN TEST IN CHRONIC PANCREATIC DISEASE
Author(s) -
Thomas E.,
Hackett E.,
O'Halloran M. W.,
Hislop I. G.,
Grant A. Kerr
Publication year - 1972
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1972.tb47123.x
Subject(s) - secretin , bicarbonate , pancreatitis , pancreatic cancer , medicine , gastroenterology , pancreas , pancreatic juice , pancreatic disease , stimulation , endocrinology , chemistry , cancer
The value of secretin stimulation of pancreatic function was statistically evaluated in 68 patients and 15 control subjects. Seventy milliequivalents per litre appeared to be the lower limit of normal bicarbonate concentration after the intravenous injection of two units per kilogram of body weight of secretin (Boots). There was a general pattern of low volume and low bicarbonate concentration in chronic pancreatitis, but a proportion of patients with proven pancreatitis exhibited bicarbonate concentrations within the normal range. Low volume and a normal bicarbonate concentration suggested pancreatic neoplasm, but volume was found to be an unreliable parameter. A low bicarbonate concentration was found in two patients with mesenteric vascular insufficiency. Cytological examination of duodenal juice proved disappointing in the small number of patients with pancreatic cancer.