Premium
DISCREPANCIES BETWEEN THE URINARY–EXCRETION AND PLASMA–LEVEL METHODS OF MEASURING VITAMIN B 12 ABSORPTION
Author(s) -
Alexander Ion S.,
Shum HingYan,
Streeter Arthur M.,
O'Neill Barry J.
Publication year - 1972
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1972.tb46738.x
Subject(s) - excretion , urine , absorption (acoustics) , plasma levels , urinary system , vitamin b12 , medicine , endocrinology , chemistry , materials science , composite material
A review is presented of 270 studies using both the urine‐excretion (Schilling test) and the plasma‐level methods of estimating radioactive vitamin B 12 absorption. In a significant proportion of these studies (13%), there were clinically important discrepancies between the results of the two methods. It is suggested that diagnostic errors are minimized when both are performed. Estimation of plasma levels of radioactivity eight and ten hours after the oral dose of 57 Co‐vitamin B 12 showed that peak plasma levels occurred at different times in different patients.