Premium
HETACILLIN IN CHILDHOOD GASTRO–ENTERITIS
Author(s) -
Lines D. R.
Publication year - 1972
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1972.tb106574.x
Subject(s) - gastro , enteritis , medicine , gastroenterology , intensive care medicine , disease , reflux
Hetacillin Is a 6‐aminopenicillanic acid, prepared by acetylation during the synthesis of ampicillin. Like that drug, it is quite non‐toxic and effective against Gram‐positive and Gram‐negative infections. Because it is very acid‐stable and has appreciable resistance to penicillinase, it was thought that it might have a role in bacterial gastro‐enteritis. Accordingly, a double‐blind trial of hetacillin compared with a placebo In the treatment of gastro‐enteritis was undertaken. It could not be shown to have a beneficial effect in the treatment of gastro‐enteritis.