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ETHCHLORVYNOL AS A SEDATIVE IN PATIENTS WITH RENAL FAILURE
Author(s) -
Dawborn J. K.,
Turner A.,
Pattisoiv G.
Publication year - 1972
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1972.tb103503.x
Subject(s) - sedative , medicine , renal function , impaired renal function , urine , urine output , kidney , drug , excretion , anesthesia , pharmacology
The use of ethchlorvynol as a sedative was investigated in patients with impaired renal function. Contrary to expectation, the blood levels of ethchlorvynol did not fall as rapidly as in normal subjects and accumulation of the drug caused drowsiness when it was used on a regular nightly basis. Although only a small proportion (about 10%) of the administered dose appears in the urine of normal subjects, it seems that the kidney plays an essential role in the metabolism or excretion of the drug, which is therefore unsuitable for use in patients with renal insufficiency.