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CARDIO‐VASCULAR EFFECTS OF ORNITHINE 8 ‐VASOPRESSIN (“POR‐8”)
Author(s) -
Einstein Rosbmarie,
Angus J. A.,
Cohbin L. B.,
Goodman A. H.
Publication year - 1971
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1971.tb92555.x
Subject(s) - vasopressin , blood pressure , aortic pressure , heart rate , medicine , cardiology , blood flow , femoral artery , coronary circulation , anesthesia
“POR‐8” (Sandoz), a synthetic vasopressin, has been used In place of adrenaline as a vasoconstrictor in surgery. The effects of Intravenous Infusion of this drug on systemic blood pressure, femoral, aortic and coronary blood flows, rate of rise of left ventricular pressure (dp/dt) and heart rate were studied in anaesthetized dogs. “POR‐8” reduced femoral and aortic blood flow and increased blood pressure, but did not affect coronary blood flow or heart rate of atropinized animals.