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RENAL VENOUS RENIN RATIO IN THE DIAGNOSIS OF RENOVASCULAR HYPERTENSION: MEASUREMENT DURING ACTIVE SECRETION OF RENIN
Author(s) -
Pawsey C. G. K.,
Vandongen R.,
Gordon R. D.
Publication year - 1971
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1971.tb87471.x
Subject(s) - renovascular hypertension , medicine , plasma renin activity , renin–angiotensin system , blood pressure , surgery , lesion , essential hypertension , urology , cardiology
Measurement of the ratio between levels of plasma renin activity in the two renal veins, sampled simultaneously, represents a safe and reliable test for the diagnosis of renovascular hypertension. A ratio (high side/low side) of 1·5 or greater suggests that a renovascular lesion exists on the high side, correction or removal of which will lead to reduction in or cure of the hypertension. For reliable results, strict attention to diet, posture and simultaneous collection of specimens is essential. In this series of 119 tests on 115 patients, only 15 patients have undergone definitive surgery. Of the 11 who have been followed for 12 months or more since operation, the results of surgery (in terms of blood pressure reduction) were correctly predicted in 10. Renal venous renin ratio determination is a valuable adjunct to intravenous pyelography and arteriography in the assessment of the hypertensive patient, and, because of minimal patient discomfort and absence of morbidity, may be useful as a screening procedure before arteriography in selected cases.