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FACTORS CONTROLLING SODIUM TRANSPORT IN THE PROXIMAL TUBULE AND THEIR RELEVANCE TO CLINICAL MEDICINE
Author(s) -
Morgan Trefor
Publication year - 1971
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1971.tb87470.x
Subject(s) - relevance (law) , sodium , medicine , renal tubule , proximal tubule , clinical significance , chemistry , kidney , political science , organic chemistry , law
The mechanism of sodium absorption from the proximal tubule and its relationship to the absorption of other substances are discussed on the basis of the Curran‐Diamond model of isotonic absorption. Emphasis is placed on the intrinsic adjustments that take place, and on the importance of simple physical factors in controlling absorption. Using the model presented in the first part of the paper, explanations are advanced for the resistance to thiazide diuretics that develops with continuous administration. In addition, the importance of increased proximal tubule absorption of sodium in various œdematous states is emphasized.