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FURTHER OBSERVATIONS ON THE USE OF THE SERUM THYROXINE ESTIMATION IN THE IN‐VITRO ASSESSMENT OF THYROID FUNCTION
Author(s) -
Murray I. P. C.,
Joasoo A.,
Parkin J.
Publication year - 1971
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1971.tb87442.x
Subject(s) - euthyroid , triiodothyronine , thyroid function , thyroid , medicine , endocrinology , free thyroxine , thyroid function tests , euthyroid sick syndrome , globulin , reproducibility , chemistry , chromatography
A review of the results of serum total thyroxine estimation in 705 patients has demonstrated that a high degree of diagnostic accuracy is achieved provided that no alteration in thyroxine‐binding globulin is present. In this situation the “free thyroxine factor”, derived from the serum thyroxine estimation and the triiodothyronine‐resin uptake, is a useful method to obtain a correct assessment of thyroid function. Misleading results may be obtained in euthyroid patients who are seriously ill as the result of non‐thyroid disorders. In these “sick euthyroid” patients, a simple technique that reflects the free thyroxine concentration has been found to be of value. A further comparison of “Tetrasorb” and “Res‐O‐Mat T 4 “ kits has demonstrated that modifications to the latter have resulted in increased reproducibility and diagnostic accuracy. The use of the serum thyroxine estimation as an index of the thyroid response to the thyroid stimulation and suppression tests is evaluated.