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SERUM FOLIC ACID AND PHENYTOIN LEVELS IN PERMANENTLY HOSPITALIZED EPILEPTIC PATIENTS RECEIVING ANTICONVULSANT DRUG THERAPY
Author(s) -
Kariks J.,
Perry S. W.,
Wood D.
Publication year - 1971
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1971.tb50600.x
Subject(s) - phenytoin , anticonvulsant , medicine , folic acid , epilepsy , drug , pharmacology , anticonvulsant drugs , antiepileptic drug , anesthesia , psychiatry
Laboratory investigations on 188 epileptic patients receiving anticonvulsant drug therapy revealed that 20% had folic acid deficiency and 23% phenytoin overdose. in view of possible permanent damage to the central nervous system due to folic acid deficiency and phenytoin intoxication, a recommendation is made for repeated serum folic acid and phenytoin estimations in all epileptic patients receiving prolonged anticonvulsant therapy.