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PLASMA SALICYLATE LEVELS IN RHEUMATOID ARTHRITIS PRODUCED BY FOUR DIFFERENT SALICYLATE PREPARATIONS
Author(s) -
Armstrong B. K.,
Tjkich A. W.,
Goatcher P. M.
Publication year - 1970
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1970.tb87379.x
Subject(s) - rheumatoid arthritis , pharmacology , sodium salicylate , medicine , chemistry
Plasma salicylate levels were measured In rheumatoid arthritic patients receiving equivalent therapeutic régimes of an aspirln/sustained release aspirin combination (“Bl‐Prln”), aloxiprin, soluble calcium aspirin and enteric‐coated sodium salicylate. Some salicylate levels obtained with aloxiprin were significantly less than those obtained with the other preparations. Twice‐daily dosage with “Bl‐Prln” did not give higher or better sustained plasma salicylate levels than four‐times‐daily dosage with other preparations. Wide variations in individual plasma salicylate levels were seen. These suggested the need to monitor these levels during salicylate therapy for rheumatoid arthritis.