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IMMUNOGLOBULIN (IgG, IgA and IgM) LEVELS IN PRIMARY CARCINOMA OF THE LIVER AND CIRRHOSIS OF THE LIVER IN SINGAPORE
Author(s) -
Chew Beng Keng,
Yu Moses,
Wee Richard
Publication year - 1970
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1970.tb84671.x
Subject(s) - cirrhosis , carcinoma , antibody , immunoglobulin m , medicine , hepatocellular carcinoma , immunoglobulin a , primary biliary cirrhosis , gastroenterology , immunoglobulin g , pathology , immunology
The serum levels of three major classes of immunoglobulins (IgG, IgA and IgM) were studied by the micro‐double‐diffusion agar plate method in 34 cases of primary carcinoma of the liver and in 36 cases of cirrhosis. It was found that in 65% of cases of primary carcinoma of the liver and in 83% of cases of cirrhosis the serum IgG level was elevated. IgA values were raised in 70% of cases of primary carcinoma of the liver and in 78% of cases of cirrhosis of the liver. No change was detected in IgM values, although in most of the cases of primary carcinoma of the liver the IgM values were well below the normal mean. The patterns of immunoglobulin levels in these two conditions were almost similar and therefore could not be used as a diagnostic aid. There was substantial correlation between the IgG and IgA values in primary carcinoma of the liver, but not in cirrhosis. The reasons for these changes are not known.