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OBSERVATIONS ON THE PHARMACOLOGY OF GAMMA HYDROXY SODIUM BUTYRATE, WITH SPECIAL REFERENCE TO MICROSURGERY OF THE LARYNX
Author(s) -
Cole W. H. J.
Publication year - 1970
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1970.tb77924.x
Subject(s) - larynx , sodium butyrate , anesthesia , nitrous oxide , medicine , stimulation , sodium , chemistry , pharmacology , surgery , biochemistry , organic chemistry , gene
Gamma hydroxy sodium butyrate is a long‐acting intravenous anæsthetic agent which has the capacity to raise blood pressure and maintain respiration at normal levels. A delay of up to eight minutes follows an intravenous injection before consciousness is lost. As in addition signs of central nervous system stimulation are sometimes present during this period, gamma hydroxy sodium butyrate is not a satisfactory intravenous agent for inducing anæsthesia. Gamma hydroxy sodium butyrate is a potentially valuable supplement to nitrous oxide. The combination of general anaesthesia with gamma hydroxy sodium butyrate, combined with local analgesia of the larynx, has been shown to provide consistently good conditions for micro‐surgical procedures on the larynx and trachea.