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TETRACYCLINE‐INDUCED TOOTH CHANGES, PART 4 DISCOLORATION AND HYPOPLASIA INDUCED BY TETRACYCLINE ANALOGUES
Author(s) -
McIntosh H. A.,
Storey E.
Publication year - 1970
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1970.tb77755.x
Subject(s) - enamel hypoplasia , hypoplasia , tooth discoloration , tetracycline , tetracycline hydrochloride , molar , dentistry , enamel paint , chemistry , medicine , antibiotics , biochemistry
The complete spectrum of tetracycline‐induced tooth disorders seen in children can be induced in the molar teeth of growing rats given different analogues of the antibiotic at different times and dose levels, or by different routes of administration. At high dose levels, some drugs induce both severe to moderate discoloration and hypoplasia, and others induce discoloration and only occasional hypoplasia, while others discolour teeth, but have no apparent effect on tooth enamel. On exposure to light, severely affected teeth become grey‐brown, those less affected become grey‐yellow, and light‐yellow ones become grey‐white and difficult to distinguish from normal. On macroscopic examination, when hypoplasia and discoloration are both taken Into account, the apparent order of decreasing severity of affection is as follows: 3 EAHTC, DMCTC, LC, TC, CTC, OTC, MC > DC, AHTC. The question as to whether clinically used antibiotics affecting teeth less, such as OTC, MC and DC, may be inducing detrimental structural changes in enamel, remains to be answered by more detailed Investigation.