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ACUTE RENAL FAILURE DUE TO OVERDOSAGE OF COLISTIN
Author(s) -
Brown J. M.,
Dorman D. C.,
Roy L. P.
Publication year - 1970
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1970.tb63262.x
Subject(s) - medicine , colistin , peritoneal dialysis , exchange transfusion , renal function , acute kidney injury , dialysis , intensive care medicine , urine output , anesthesia , antibiotics , microbiology and biotechnology , biology
A male child, aged 10 months, was accidentally given a massive overdose of colistin methanesulphonate. He developed acute renal failure. He was anuric for 36 hours. Peritoneal dialysis was used, both for treatment of the acute renal failure and in an attempt to remove the drug. After 24 hours the estimated serum level was unchanged. Two exchange transfusions were subsequently given. He began to pass urine again just before the first exchange transfusion. No neurotoxicity was observed. Renal function has apparently returned to normal. It is suggested that exchange transfusion is the only way to remove a significant quantity of the drug, but that the management of any associated acute renal failure should be the prime concern.