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INFLUENCE OF ABO BLOOD GROUPS ON THE SELECTIVE DISAGGREGATION OF THE RED CELLS CAUSED BY DRUG RA433
Author(s) -
Dintenfass Leopold
Publication year - 1970
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1970.tb63208.x
Subject(s) - abo blood group system , drug , in vitro , pharmacology , immunology , chemistry , medicine , biology , biochemistry
Addition of the drug RA433 (of the “Persantin” group) to blood in vitro resulted in a selective disaggregation (or selective aggregation) of the red cells. This selective effect appears to be related to the blood group, the antigen‐A‐containing blood groups showing a statistically significant increase in the negative responses. The blood of patients with carcinoma showed also a statistically significant increase in the number of negative responses (that is, the occurrence of an increased degree of aggregation of the red cells).