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THE TREATMENT OF DERMATOLOGICAL INFECTIONS WITH A MANGANESE PHENANTHROLINE CHELATE: A CONTROLLED CLINICAL TRIAL
Author(s) -
Cade Gina,
Shankly K. H.,
Shulman A.,
Wright R. D.,
Stahle I. O.,
MacGibbon C. B.,
LewSang Elizabeth
Publication year - 1970
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1970.tb50011.x
Subject(s) - chelation , manganese , antimicrobial , medicine , potency , phenanthroline , microbiology and biotechnology , chemistry , biology , inorganic chemistry , biochemistry , organic chemistry , in vitro
The antimicrobial action of two preparations containing a manganese (II) chelate of 3, 4, 7, 8–tetramethyl–1, 10–phenanthroline has been compared clinically with that of control substances of known high potency. The trial involved 151 patients, including many with chronic dermatological infections due to dermatophytes or Candida. The underlying condition and its progress were verified by microbiological examination. No toxic manifestations were observed with the manganese chelates, which were equally as active as the control preparations in about 50% of cases. Significant microbial resistance to the chelates did not develop. It is considered that the manganese and related metal chelates warrant further study in the treatment of topical infections due to pathogenic bacteria and fungi.