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AN OPTIMAL ZONE OF COLISTIN ACTIVITY WITH SERRATIA MARCESCENS
Author(s) -
Annear D. I.
Publication year - 1970
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1970.tb49948.x
Subject(s) - serratia marcescens , colistin , microbiology and biotechnology , serratia , antibiotics , agar , agar dilution , agar dilution method , enterobacteriaceae infections , antibiotic sensitivity , biology , chemistry , enterobacteriaceae , bacteria , minimum inhibitory concentration , escherichia coli , biochemistry , pseudomonas , genetics , gene
Fifteen isolates of Serratia marcescens have been shown to yield unusual zones in disc sensitivity tests with colistin. More extensive tests have been performed on two of these Isolates, and these have shown clear evidence of inhibition by an optimal concentration of the antibiotic. With the agar‐plate dilution method of sensitivity measuring, paradoxically, lower recoveries of the organisms were obtained at colistin concentrations of approximately 5 μ g/ml than at concentrations of more than 1,000 μ g/ml. With the disc method of testing, these organisms may give false indications of sensitivity to the drug.