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PROFOUND LEUKOPENIA FOLLOWING ASPARAGINASE TREATMENT IN A PATIENT WITH ACUTE LYMPHOBLASTIC LEUKAEMIA
Author(s) -
Oehlers M. J.,
Fetawadjieff W.,
Woodliff H. J.
Publication year - 1969
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1969.tb107492.x
Subject(s) - leukopenia , asparaginase , chemotherapy , medicine , bone marrow , lymphoblastic leukemia , toxicity , acute lymphocytic leukemia , cancer research , immunology , gastroenterology , leukemia
We report a case of profound leukopenia following l‐asparaginase treatment in a patient with acute lymphoblastic leukæmia. I‐Asparaginase raises a new concept in cancer chemotherapy, in that it removes an essential nutrient from sensitive malignant cells. It has been said to have no inherent toxicity for normal cells, but in this case appeared to depress the normal cellular elements of the bone marrow. Cellular sensitivity to the enzyme appears to be variable, and in‐vitro sensitivity tests should prove of value in the control of treatment.