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CARBENICILLIN THERAPY IN RENAL FAILURE
Author(s) -
Johny M.,
Derrington A. W.,
Lawrence J. E.,
Clapp K. H.
Publication year - 1969
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1969.tb107344.x
Subject(s) - carbenicillin , intensive care medicine , medicine , chemistry , biochemistry , antibiotics , ampicillin
Carbenicillin dosage schedules have been studied by serum and urine assay in patients with pseudomonas infections and varying degrees of renal failure. In the absence of antibiotic assay we recommend a loading dose of 2 gm of carbenicillin followed by 1 gm given intramuscularly every six hours, in the presence of renal failure, for uncomplicated urinary, respiratory and wound infections. A dose of 2 gm every six hours is necessary with recovery of reasonable renal function, and during peritoneal dialysis and hæmodlalysis. In renal failure with pseudomonas septicæmia, an intravenous loading dose of 4 gm, followed by 2 to 4 gm every six hours by slow intravenous injection or continuous infusion would seem adequate. Additional doses would be needed during dialysis and gentamicin may have to be added in complicated cases. The degree of serum binding of carbenicillin appears to be similar to but firmer than that of benzyl penicillin, and the validity of ultrafiltration in the measurement of free unbound antibiotic is questioned.