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CYSTIC FIBROSIS
Author(s) -
T Morony
Publication year - 1968
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1968.tb28725.x
Subject(s) - citation , field (mathematics) , cystic fibrosis , computer science , library science , psychology , medicine , mathematics , pure mathematics
CYSTIO FIBBOSIS is not a new disease. Long before Dorothy Anderson's publication in 1938' of the first of a series of reports on the syndrome she named cystic fibrosis of the pancreas, infants and young children with steatorrhcea, stunting of growth and abdominal distension were dying from respiratory infections and "heat exhaustion". Early in this century the association between the gastro-intestinal and respiratory manifestations of the disease was recognized, and its inheritance as a Mendelian recessive was suggested. Later work has filled in details of the clinico-pathological entity we know today, the most recent significant contribution having been made in 1949 with the recognition of the high incidence of prostration among fibrocystic infants during heat wave conditions. This led directly to the discovery of the abnormally high concentration of sodium, potassium and chloride in the sweat of affected children (di Sant'Agnese et alii") and to the familiar "sweat test"--one of medicine's most accurate diagnostic tools.