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Pathology
Publication year - 1966
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1966.tb72597.x
Subject(s) - citation , computer science , psychology , information retrieval , library science
malonate. Various sulphhydryl inhibitors and the adjuvants were tested individually and in combination against animal tumours, and in every case there was close correlation between the agar plate result and the clinical effect. The drug oxophenarsine, which has little activity against animal tumours by itself, was found to be even more effective than mercaptopurine or thio-tepa when combined with an adjuvant. Again the clinical effect was in accordance with the agar plate result. The clinical response of human tumours was also found to be predicable by the agar plate method, and the development of drug resistance could also be demonstrated.