Physiology

sive. The attack rate of hepatitis with jaundice among inoculated patients (mainly children) was about a third of that in the uninoculated group, but among the attendants (all adults) there was no evidence that this dosage had conferred any protection. In the subsequent trials a dose of 0·06 ml, per pound was used, and with this dosage in the second trial the incidence of overt hepatitis among inoculated children was only one-tenth of that in the uninoculated group. Krugman et alii conclude that the optimum dose of gamma globulin is 0·06 ml. per pound of body weight, but they note that even this dosage may not prevent anicteric hepatitis.