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THERAPEUTICS
Publication year - 1958
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1958.tb86344.x
Subject(s) - citation , computer science , information retrieval , world wide web
D. F. CAPPELL, H. E. HUTCHISON AND M. JOWETT (J. Path. &: Bact., October, 1957) have studied five cases of transfusional siderosis, chemically and histologically. Two of their patients had received 600 and 800 pints of blood respectively and had survived six and a half and 12 years. Over 55 grarnmes of iron were present in the liver in each case, an amount twice that usually found in luemochromatosis, yet cirrhosis was absent. The distribution of iron is compared with other forms of severe siderosis in man. Analysis of the literature indicates that, contrary to general belief, luemochromatosis is seldom present in transfusional cases. When it is, chemical analysis shows that the iron is not wholly attributable to the transfusions, but must have been caused to a considerable extent by continued absorption from the gut. The implications of this finding are discussed.