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THE MAYO BROTHERS
Author(s) -
H Clapesattle
Publication year - 1942
Publication title -
medical journal of australia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 131
eISSN - 1326-5377
pISSN - 0025-729X
DOI - 10.5694/j.1326-5377.1942.tb96348.x
Subject(s) - citation , library science , psychology , computer science , information retrieval
On the basis of his experimentswith procaine in the treatment of experimental infections with Clostridium 1celchii in guinea-pigs,Hawking") has suggestedthat local anrestheticagentsof the p-aminobenzoicacid class should not be used in surgery unless it is certain that sulphonamides will not be used within the following twenty-four hours. Until further work gives a more precise answer to the problem, the experimentsreported here suggestthat only in a few conditions would the danger from procaine and other local aneesthettcagents of the p-amtnobensotcacid classbe so great as to contraindicatetheir use.' They are contraindicated (i) when the patient is so seriously infected that even a slight delay in treatment with sulphonamidesmay diminish the chancesof survival, and (ii), when massive tissue damage is present, and the circulation in the damaged tissue is poor, so that the removal of traminobenzoicacid from the tissue after the use of procaine may be very slow. This might enable a wound infection, which would otherwiseperhapshave been kept in check with the sulphonamide, to become established.