KIDNEY DISEASE

tumour. The idea of a pineal tumour as the causeof the macrogenitosomiawas discountedby the absenceof intracranial pressure(no hydrocephalus);lack of visual symp'toms ruled out chiasmal glioma. There was, indeed, no ' definite indication of any cerebral tumour. All that, appearedwas the suggestionof hyperfunctionof the basophile cells without involvement of the other elementsof the anterior pituitary lobe and without malformation of the gland. But certitude was wanting; the same symptomatology has been associatedwith hyperplasia of the adrenal cortex without pituitary lesion. Consequentlyno operative nor other remedial measureoffered promise of benefit, and the child was discharged from hospital to attend as an out-patient,which he did at intervals during the next two years. On November 17, 1931, some twoyears after his first visit, he was again brought into hospital, having had six to twelve fits daily for a week, and having been unconscious for two days. He died next day.