Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1α protein | Zendy

Agata Gabryelska | Zendy; Bartosz Szmyd | Zendy; Janusz Szemraj | Zendy; Robert Stawski | Zendy; Marcin Sochal | Zendy; Piotr Białasiewicz | Zendy

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Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1α protein

Author(s) -

Agata Gabryelska,

Bartosz Szmyd,

Janusz Szemraj,

Robert Stawski,

Marcin Sochal,

Piotr Białasiewicz

Publication year - 2020

Publication title -

journal of clinical sleep medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 92

eISSN - 1550-9397

pISSN - 1550-9389

DOI - 10.5664/jcsm.8682

Subject(s) - morning , polysomnography , evening , medicine , obstructive sleep apnea , sleep apnea , endocrinology , apnea , physics , astronomy

Obstructive sleep apnea (OSA) is a chronic condition that is characterized by recurrent pauses in breathing during sleep causing intermittent hypoxia. The main factor responsible for oxygen metabolism homeostasis is hypoxia-inducible factor 1 (HIF-1), comprised of 2 subunits: α (oxygen sensitive) and β. The aim of the study was to investigate the HIF-1α serum protein level and mRNA HIF-1α expression in patients with OSA and a healthy control group and determine their evening-morning variation and association with polysomnography parameters.

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