Restless Legs Syndrome in Chronic Kidney Disease: Is Iron or Inflammatory Status To Blame? | Zendy

Sandeep K. Riar | Zendy; Larry A. Greenbaum | Zendy; Donald L. Bliwise | Zendy; Roberta M. Leu | Zendy

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Restless Legs Syndrome in Chronic Kidney Disease: Is Iron or Inflammatory Status To Blame?

Author(s) -

Sandeep K. Riar,

Larry A. Greenbaum,

Donald L. Bliwise,

Roberta M. Leu

Publication year - 2019

Publication title -

journal of clinical sleep medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 92

eISSN - 1550-9397

pISSN - 1550-9389

DOI - 10.5664/jcsm.8028

Subject(s) - medicine , kidney disease , ferritin , restless legs syndrome , transferrin saturation , pathogenesis , gastroenterology , iron deficiency , transferrin , inflammation , dialysis , endocrinology , immunology , anemia , psychiatry , neurology

Restless legs syndrome (RLS) is increased in pediatric chronic kidney disease (CKD). In adults without CKD, central nervous system iron deficiency is involved in RLS pathogenesis and a low serum ferritin levels is consequently an indication for initiation of iron therapy. However, children with CKD are at risk for iron deficiency and inflammation, which raises serum ferritin. We examined the role of iron deficiency and inflammation in RLS in pediatric CKD.

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