Alpha-1 Adrenergic-Antagonist Use Increases the Risk of Sleep Apnea: A Nationwide Population-Based Cohort Study | Zendy

PoLan Su | Zendy; Wen-Kuei Lin | Zendy; Cheng-Yu Lin | Zendy; ShengHsiang Lin | Zendy

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Alpha-1 Adrenergic-Antagonist Use Increases the Risk of Sleep Apnea: A Nationwide Population-Based Cohort Study

Author(s) -

PoLan Su,

Wen-Kuei Lin,

Cheng-Yu Lin,

ShengHsiang Lin

Publication year - 2019

Publication title -

journal of clinical sleep medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 92

eISSN - 1550-9397

pISSN - 1550-9389

DOI - 10.5664/jcsm.8014

Subject(s) - medicine , sleep apnea , obstructive sleep apnea , hazard ratio , apnea , adrenergic antagonist , confidence interval , confounding , continuous positive airway pressure , antagonist , anesthesia , receptor

Decreased upper-airway muscle responsiveness is one of the major phenotypes of obstructive sleep apnea. Use of α1-adrenergic antagonists is correlated with decreased muscle responsiveness in animal studies, but this association has not yet been demonstrated in humans. This study examined whether use of α1-adrenergic antagonists is an independent risk factor for sleep apnea in humans.

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