Exosomal Cargo Properties, Endothelial Function and Treatment of Obesity Hypoventilation Syndrome: A Proof of Concept Study | Zendy

Rakesh Bhattacharjee | Zendy; Abdelnaby Khalyfa | Zendy; Ahamed Khalyfa | Zendy; Babak Mokhlesi | Zendy; David Gozal | Zendy; Isaac Almendros | Zendy; Eduard Peris | Zendy; Atul Malhotra | Zendy

Open Access

Exosomal Cargo Properties, Endothelial Function and Treatment of Obesity Hypoventilation Syndrome: A Proof of Concept Study

Author(s) -

Rakesh Bhattacharjee,

Abdelnaby Khalyfa,

Ahamed Khalyfa,

Babak Mokhlesi,

David Gozal,

Isaac Almendros,

Eduard Peris,

Atul Malhotra

Publication year - 2018

Publication title -

journal of clinical sleep medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 92

eISSN - 1550-9397

pISSN - 1550-9389

DOI - 10.5664/jcsm.7110

Subject(s) - sleep medicine , medicine , section (typography) , library science , gerontology , psychiatry , computer science , sleep disorder , operating system , cognition

Longitudinal studies support the usage of positive airway pressure (PAP) therapy in treating obstructive sleep apnea (OSA) to improve cardiovascular disease. However, the anticipated benefit is not ubiquitous. In this study, we elucidate whether PAP therapy leads to immediate improvements on endothelial function, a subclinical marker of cardiovascular status, by examining the effect of circulating exosomes, isolated from patients before and after PAP therapy, on naive endothelial cells.

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