Open AccessBiomarkers of oxidative stress in erythrocytes as a function of human age
Author(s) -
Pawan Kumar Maurya,
Prabhanshu Kumar,
Pranjal Chandra
Publication year - 2015
Publication title -
world journal of methodology
Language(s) - English
Resource type - Journals
ISSN - 2222-0682
DOI - 10.5662/wjm.v5.i4.216
Subject(s) - oxidative stress , antioxidant , reactive oxygen species , enzyme , oxidative phosphorylation , biochemistry , function (biology) , cell , microbiology and biotechnology , organism , red blood cell , chemistry , biology , genetics
Despite more than 300 theories to explain the aging process, oxidative stress theory offers the best mechanism to explain aging and age related disorders. Several studies has shown the importance of oxidative stress during aging. PubMed, Science Direct and Springer online data bases are taken into consideration to write this mini-review. Human erythrocytes are most abundant and specialized cells in the body. Erythrocytes were extensively studied due to their metabolism and gas transport functions. Recent studies on erythrocytes have provided us detailed information of cell membrane and its structural organization that may help in studying the aging and age associated changes. The susceptibility of an organism is associated with the antioxidant potential of the body. Erythrocytes have potent antioxidant protection consisting of enzymatic and non-enzymatic pathways that counteract with reactive oxygen species, thus maintaining the redox regulation in the body. The non-enzymatic and enzymatic antioxidants and other biomarkers associated with erythrocyte membrane transport functions are the main content of this review. Biomarkers of oxidative stress in erythrocytes and its membrane were taken into the consideration during human aging that will be the main subject of this mini- review.