Open AccessRefractory chronic cough due to gastroesophageal reflux: Definition, mechanism and management
Author(s) -
Hanjing Lv,
Zhongmin Qiu
Publication year - 2015
Publication title -
world journal of methodology
Language(s) - English
Resource type - Journals
ISSN - 2222-0682
DOI - 10.5662/wjm.v5.i3.149
Subject(s) - reflux , chronic cough , medicine , refractory (planetary science) , baclofen , esophageal sphincter , gastroenterology , medical therapy , anesthesia , asthma , intensive care medicine , disease , agonist , receptor , physics , astrobiology
Refractory chronic cough due to gastroesophageal reflux is a troublesome condition unresponsive to the standard medical anti-reflux therapy. Its underlying mechanisms may include incomplete acid suppression, non-acid reflux, transient lower esophageal sphincter relaxations and esophageal hypersensitivity. The diagnosis of this disorder depends on both the findings of multi-channel intraluminal impedance-pH monitoring and the subsequent intensified anti-reflux therapy. The strategies of pharmacological treatment for refractory chronic cough due to reflux include the optimization of proton pump inhibitors and add-on therapies with histamine H2 receptor antagonists, baclofen and gabapentin. However, the further study is needed to satisfy its management.