Open AccessAdult stem cell-based apexogenesis
Author(s) -
Yao Li,
Li-Hong Shu,
Ming Yan,
Wei Dai,
Jun Li,
Guangdong Zhang,
Jinhua Yu
Publication year - 2014
Publication title -
world journal of methodology
Language(s) - Uncategorized
Resource type - Journals
ISSN - 2222-0682
DOI - 10.5662/wjm.v4.i2.99
Subject(s) - dentistry , pulpitis , root canal , pulp (tooth) , medicine , regenerative medicine , stem cell , endodontic therapy , periodontitis , dental pulp stem cells , orthodontics , biology , pathology , mesenchymal stem cell , microbiology and biotechnology
Generally, the dental pulp needs to be removed when it is infected, and root canal therapy (RCT) is usually required in which infected dental pulp is replaced with inorganic materials (paste and gutta percha). This treatment approach ultimately brings about a dead tooth. However, pulp vitality is extremely important to the tooth itself, since it provides nutrition and acts as a biosensor to detect the potential pathogenic stimuli. Despite the reported clinical success rate, RCT-treated teeth are destined to be devitalized, brittle and susceptible to postoperative fracture. Recently, the advances and achievements in the field of stem cell biology and regenerative medicine have inspired novel biological approaches to apexogenesis in young patients suffering from pulpitis or periapical periodontitis. This review mainly focuses on the benchtop and clinical regeneration of root apex mediated by adult stem cells. Moreover, current strategies for infected pulp therapy are also discussed here.