Open AccessProtein dynamicsviacomputational microscope
Author(s) -
Anton B. Guliaev,
Senping Cheng,
Bo Hang
Publication year - 2012
Publication title -
world journal of methodology
Language(s) - Uncategorized
Resource type - Journals
ISSN - 2222-0682
DOI - 10.5662/wjm.v2.i6.42
Subject(s) - molecular dynamics , millisecond , computer science , field (mathematics) , current (fluid) , folding (dsp implementation) , protein folding , nanotechnology , computational science , chemistry , physics , computational chemistry , materials science , engineering , mathematics , mechanical engineering , biochemistry , astronomy , pure mathematics , thermodynamics
The purpose of this overview is to provide a concise introduction to the methodology and current advances in molecular dynamics (MD) simulations. MD simulations emerged as a powerful and popular tool to study dynamic behavior of proteins and macromolecule complexes at the atomic resolution. This approach can extend static structural data, such as X-ray crystallography, into dynamic domains with realistic timescales (up to millisecond) and high precision, therefore becoming a veritable computational microscope. This perspective covers current advances and methodology in the simulation of protein folding and drug design as illustrated by several important published examples. Overall, recent progress in the simulation field points to the direction that MD will have significant impact on molecular biology and pharmaceutical science.