Open Accessp75NTR receptor – role in cell growth and apoptosis
Author(s) -
Anna Urbaniak
Publication year - 2012
Publication title -
postępy higieny i medycyny doświadczalnej
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 34
eISSN - 1732-2693
pISSN - 0032-5449
DOI - 10.5604/17322693.999026
Subject(s) - trk receptor , neurotrophin , low affinity nerve growth factor receptor , microbiology and biotechnology , receptor tyrosine kinase , hyperphosphorylation , receptor , tropomyosin receptor kinase c , biology , tropomyosin receptor kinase a , signal transduction , nerve growth factor , tropomyosin receptor kinase b , neuroscience , neurotrophic factors , phosphorylation , growth factor , platelet derived growth factor receptor , biochemistry
The neurotrophins play an important role in the development of the nervous system. These trophic factors affect the cells through the neurotrophin receptors Trk and p75NTR. Trk (tyrosine kinase receptor) mediated signaling promotes survival and growth, while p75NTR-mediated signaling promotes cell death. The structure of p75NTR and its role in the regulation of survival, growth and induction of apoptosis are discussed. p75NTR can interact with the aggregated form of Aβ peptides and by influencing protein tau hyperphosphorylation plays an important role in etiopathogenesis of Alzheimer's disease.