Open AccessTransmembrane transporters ABCC – structure, function and role in multidrug resistance of cancer cells
Author(s) -
S Dębska,
Agata Owecka,
Urszula Czernek,
Katarzyna Szydłowska-Pazera,
Maja Habib,
Piotr Potemski
Publication year - 2011
Publication title -
postępy higieny i medycyny doświadczalnej
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 34
eISSN - 1732-2693
pISSN - 0032-5449
DOI - 10.5604/17322693.956500
Subject(s) - efflux , multiple drug resistance , atp binding cassette transporter , subfamily , cancer cell , biology , cytotoxic t cell , drug resistance , cancer , transmembrane protein , multidrug resistance associated proteins , transporter , function (biology) , cancer research , microbiology and biotechnology , biochemistry , gene , genetics , receptor , in vitro
Resistance to cytotoxic drugs is a significant problem of systemic treatment of cancers. Apart from drug inactivation, changes in target enzymes and proteins, increased DNA repair and suppression of apoptosis, an important mechanism of resistance is an active drug efflux from cancer cells. Drug efflux across the cell membrane is caused by transport proteins such as ABC proteins (ATP-binding cassette). This review focuses on the ABCC protein subfamily, whose members are responsible for multidrug cross-resistance of cancer cells to cytotoxic agents. The authors discuss the structure of ABCC proteins, their physiological function and diseases provoked by mutations of respective genes, their expression in many different malignancies and its connection with resistance to anticancer drugs, as well as methods of reversion of such resistance.