Open AccessEndothelial progenitor cells as a new marker of endothelial function with respect to risk of cardiovascular disorders
Author(s) -
Barbara Głowińska-Olszewska,
Włodzimierz Łuczyński,
Artur Bossowski
Publication year - 2011
Publication title -
postępy higieny i medycyny doświadczalnej
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 34
eISSN - 1732-2693
pISSN - 0032-5449
DOI - 10.5604/17322693.931086
Subject(s) - progenitor cell , vasculogenesis , endothelial progenitor cell , endothelial dysfunction , hyperlipidemia , medicine , diabetes mellitus , population , endothelial stem cell , pathogenesis , bioinformatics , immunology , stem cell , biology , endocrinology , genetics , environmental health , in vitro
The discovery of endothelial progenitor cells (EPC), over a decade ago, has refuted the previous belief that vasculogenesis only occurs during embryogenesis. The results of several studies revealed altered number and impaired function of EPC in hyperlipidemia, hypertension, diabetes, obesity as well as in rheumatoid arthritis. The population of developmental age is characterized by higher counts of EPC compared to adults. However, among young patients with chronic disorders that affect the vascular system, the number of EPC decreases. The reduced circulating concentration of EPC has become a surrogate marker of endothelial function and has been implicated in the pathogenesis of many vascular diseases. This article aims to review the biology and pathophysiology of EPC in the conditions of cardiovascular risk factors. The potential possibilities of increasing EPC number and function as well as the use of EPC in the treatment of vascular pathology will also be discussed.