Open AccessPro-angiogenic cytokines in systemic sclerosis
Author(s) -
Ewa Robak,
Zofia Gerlicz
Publication year - 2014
Publication title -
postępy higieny i medycyny doświadczalnej
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 34
eISSN - 1732-2693
pISSN - 0032-5449
DOI - 10.5604/17322693.1132008
Subject(s) - angiogenesis , vasculogenesis , medicine , fibrosis , urokinase receptor , endoglin , neovascularization , cancer research , immunology , pathology , biology , progenitor cell , receptor , microbiology and biotechnology , stem cell , cd34
Systemic sclerosis (SSc) is a multifactorial connective tissue disease characterized by excessive and progressive fibrosis along with microvasculopathy due to poor vascular formation and repair. Despite a general increase in many potent angiogenic factors, the vasculopathy compensatory angiogenesis and vasculogenesis are impaired. In this review, we discuss the role of proangiogenic factors--VEGF, PlGF, endoglin, PDGF, endothelin-1, angiopoietins, SDF-1, uPAR--and the paradoxical paucity of an inadequate angiogenic response in SSc.