Open AccessThe potential nephrotoxicity of antiretroviral drugs
Author(s) -
Zofia Marchewka,
Beata Szymańska,
Joanna Płonka
Publication year - 2012
Publication title -
postępy higieny i medycyny doświadczalnej
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 34
eISSN - 1732-2693
pISSN - 0032-5449
DOI - 10.5604/17322693.1011471
Subject(s) - nephrotoxicity , intensive care medicine , medicine , human immunodeficiency virus (hiv) , antiretroviral agents , nephropathy , antiretroviral therapy , antiretroviral drug , drug , pharmacology , kidney , immunology , viral load , diabetes mellitus , endocrinology
The intensive studies carried out in many scientific laboratories and the efforts of numerous pharmaceutical companies have led to the development of drugs which are able to effectively inhibit HIV proliferation. At present, a number of antiretroviral agents with different mechanisms of action are available. Unfortunately, long-term use of antiretroviral drugs, however, does not remain indifferent to the patient and can cause significant side effects. In the present work, the antiretroviral drugs with a nephrotoxicity potential most commonly used in clinical practice are described. In the review attention has also been focused on the nephropathy resulting from the HIV infection alone and the influence of genetic factors on the occurrence of pathological changes in the kidney.